Pharmacokinetics Studies

Our services include:

 

  • PK program studies
  • Routine single or multiple dose PK studies
  • Oral, ocular, dermal, intratracheal, intravitreal, intravenous,intramuscular, subcutaneous, intrapretoneal, joint fluid, short-infusion and other routs of   administration.
  • Pharmacokinetic-pharmacodynamic studies in disease models such as tumor-bearing animals, infection models, inflammation models, metabolic diseases, and surgical animals
  • Radionuclide studies
  • MRSA nasal inoculations
 
Classes of Compounds

  •  
    Our services include evaluations of following compounds:

    • Pharmaceuticals
    • Proteins
    • Other biotech products
    • Veterinary products
    • Synthetic and organic chemicals
    • Pesticides
    • Food additives
    • Stem cell
 
Isolated organ perfusion

 

Isolated organs of animals are perfused by an artificial blood circulation system with body-warm whole blood. The most modern methods from the internal medicine and from the transplantation medicine are used. Substances and cosmetics can be tested in such a way. The effect of a substance on a defined organ can be examined without interference by other organs.
 
Species

Preclinical studies have utilized numerous species of laboratory animal models in SPF conditions, including:

  •   Rodents
  •   Minipigs
  •   German domestic pigs
  •   Goat
  •   Sheep
  •   Dogs
 
Medical Device

 

  •  
    Our in vivo medical device testing services include:

    •  Implantation testing
    •  Function testing
    •  Local irritation testing
    •  Biocompatibility testing
    •  Pyrogenicity testing
    •  Sensitation testing
    •  Physician hands-on-training 
 
Classes of medical Devices

  •  
    Our services include in vivi testing of:

    • Coronary stent
    • PFO, ASD occluder
    • Cardiovascular catheter
    • Central venous catheter
    • Cardiac pacemaker
    • Artificial heart
    • Artificial cardiac valve
    • Indwelling catheter
    • Peritoneal catheter
    • Intracarneal pressure measurement
    • Orthopedic device
    • Bone cement
    • Bone substitute
    • Cartilage substitute
    • Guded bone regeneration material
 
Route of administration

  •  

    Most drugs are manufactured for a specific route of administration.

    We are able to administrate substances using several routs and methods:
     

    • Gavage, dietary, ocular and dermal
    •  Intravenous, intrapretoneal, subcutaneous injection or infusion
    •  Intratracheal and intranasal instillation
    •  Nasal inoculation
    •  Intravitreal
    •  Intraventricular and intraaortic
    •  Intrahecal, intravaginal
    •  Single dose and multiple dose
    •  Continuous dosing using osmotic pumps